![Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6 -dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine- 6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of ... Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6 -dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine- 6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of ...](https://pubs.acs.org/cms/10.1021/jm4019299/asset/images/large/jm-2013-019299_0014.jpeg)
Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6 -dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine- 6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of ...
Conformational Flexibility, Internal Hydrogen Bonding, and Passive Membrane Permeability: Successful in Silico Prediction of the Relative Permeabilities of Cyclic Peptides | Journal of the American Chemical Society
![Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020 - The Lancet Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020 - The Lancet](https://www.thelancet.com/cms/asset/50ef5d81-7f84-4082-9285-c3e3fa823def/gr1.jpg)
Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020 - The Lancet
![Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial - The Lancet Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial - The Lancet](https://www.thelancet.com/cms/attachment/5bed4511-a715-4762-8597-b8dc13b1016d/gr1.gif)
Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial - The Lancet
Discontinuation and tapering of prescribed opioids and risk of overdose among people on long-term opioid therapy for pain with and without opioid use disorder in British Columbia, Canada: A retrospective cohort study
![Estimating global, regional, and national daily and cumulative infections with SARS-CoV-2 through Nov 14, 2021: a statistical analysis - The Lancet Estimating global, regional, and national daily and cumulative infections with SARS-CoV-2 through Nov 14, 2021: a statistical analysis - The Lancet](https://www.thelancet.com/cms/asset/14dc13b0-bd83-4d16-8eee-da19a6b8acdc/gr1.jpg)
Estimating global, regional, and national daily and cumulative infections with SARS-CoV-2 through Nov 14, 2021: a statistical analysis - The Lancet
![β-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway | Communications Biology β-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway | Communications Biology](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs42003-022-03369-x/MediaObjects/42003_2022_3369_Fig1_HTML.png)
β-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway | Communications Biology
![Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21 - The Lancet Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21 - The Lancet](https://www.thelancet.com/cms/asset/33676324-183e-40d4-8810-e27d8df79b58/gr1.jpg)
Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21 - The Lancet
![Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019 - The Lancet Public Health Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019 - The Lancet Public Health](https://www.thelancet.com/cms/asset/48229e90-0166-4370-a0ac-56c0672097ba/gr1.jpg)
Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019 - The Lancet Public Health
![Targeting galectin-driven regulatory circuits in cancer and fibrosis | Nature Reviews Drug Discovery Targeting galectin-driven regulatory circuits in cancer and fibrosis | Nature Reviews Drug Discovery](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41573-023-00636-2/MediaObjects/41573_2023_636_Fig1_HTML.png)
Targeting galectin-driven regulatory circuits in cancer and fibrosis | Nature Reviews Drug Discovery
![COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records - The Lancet Digital Health COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records - The Lancet Digital Health](https://www.thelancet.com/cms/asset/4d04d9a4-8499-4cbb-aa79-c6c0d7d337a5/gr1.jpg)
COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records - The Lancet Digital Health
![The season for large fires in Southern California is projected to lengthen in a changing climate | Communications Earth & Environment The season for large fires in Southern California is projected to lengthen in a changing climate | Communications Earth & Environment](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs43247-022-00344-6/MediaObjects/43247_2022_344_Fig1_HTML.png)